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  • Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

    Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

    Inbunden - 2008 - Engelska - ISBN: 9783764385514

    Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, ca…

  • Regulatory T Cells in Inflammation

    Regulatory T Cells in Inflammation

    Inbunden - 2005 - Engelska - ISBN: 9783764370886

    Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppre…

  • The Inflammasomes

    The Inflammasomes

    Inbunden - 2011 - Engelska - ISBN: 9783034801478

    The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the iden…

  • The Inflammasomes

    The Inflammasomes

    Häftad - 2013 - Engelska - ISBN: 9783034803434

    The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the iden…

  • Medicinal Fatty Acids in Inflammation

    Medicinal Fatty Acids in Inflammation

    Inbunden - 1998 - Engelska - ISBN: 9783764358549

    This volume of Progress in Inflammation Research is a unique compilation of work performed by a wide spectrum of investigators from different medical disciplines. It is fascinating that dietary alterations of fatty acid intake can result in a range…

  • Arachidonate Remodeling and Inflammation

    Arachidonate Remodeling and Inflammation

    Häftad - 2012 - Engelska - ISBN: 9783034895941

    Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Rem…

  • IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

    IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

    Inbunden - 2012 - Engelska - ISBN: 9783034805216

    The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has…

  • IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

    IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

    Häftad - 2015 - Engelska - ISBN: 9783034807739

    The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has…

  • Inflammation and Cardiac Diseases

    Inflammation and Cardiac Diseases

    Inbunden - 2003 - Engelska - ISBN: 9783764367251

    Heart failure research is a most active area of research in academic, industrial and government-sponsored research and receives intense clinical attention. The recent recognition that inflammation is a risk factor and prognostic factor for heart dis…

  • Fatty Acids and Inflammatory Skin Diseases

    Fatty Acids and Inflammatory Skin Diseases

    Häftad - 2012 - Engelska - ISBN: 9783034897624

    Fatty acids play an important role in the barrier function of skin and represent a major source of proinflammatory mediators such as prostaglandins, leukotrienes and other lipids in inflammatory skin disorders. This book combines the two major funct…

  • Migraine: A Neuroinflammatory Disease?

    Migraine: A Neuroinflammatory Disease?

    Häftad - 2012 - Engelska - ISBN: 9783034894494

    This book contains reviews by a renowned group of clinicians and scientists, which consider in great depth the potential involvement of neurogenic inflammation in the pathogenesis of migraine and inhibition of this putative mechanism as a possible m…

  • Bone Morphogenetic Proteins: Systems Biology Regulators

    Bone Morphogenetic Proteins: Systems Biology Regulators

    Inbunden - 2017 - Engelska - ISBN: 9783319475059

    This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and d…

  • Free Radicals and Inflammation

    Free Radicals and Inflammation

    Häftad - 2012 - Engelska - ISBN: 9783034895866

    As in so many fields of scientific endeavour following the molecular biology revo lution, our knowledge of the role of radicals not only in pathological states, but in basic physiology has developed exponentially. Indeed, our evolving concepts have,…

  • Cytokines and Joint Injury

    Cytokines and Joint Injury

    Inbunden - 2004 - Engelska - ISBN: 9783764370015

    The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevanc…

  • TGF-  and Related Cytokines in Inflammation

    TGF- and Related Cytokines in Inflammation

    Häftad - 2012 - Engelska - ISBN: 9783034895316

    The TGF-13 superfamily is a large and expanding multigene family which in verte- brates includes the TGF-13 proteins themselves, the bone morphogenetic proteins (BMPs), the growth and differentiation factors (GDF), the activins/inhibins (INH), Mulle…

  • MicroRNAs and Other Non-Coding RNAs in Inflammation

    MicroRNAs and Other Non-Coding RNAs in Inflammation

    Häftad - 2016 - Engelska - ISBN: 9783319382302

    The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohn's disease, diabetes)…

  • Matrix Metalloproteinases in Tissue Remodelling and Inflammation

    Matrix Metalloproteinases in Tissue Remodelling and Inflammation

    Inbunden - 2008 - Engelska - ISBN: 9783764385842

    This volume provides new advances regarding the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs give new insights in the relationship…

  • Migraine: A Neuroinflammatory Disease?

    Migraine: A Neuroinflammatory Disease?

    Inbunden - 2002 - Engelska - ISBN: 9783764362317

    This book contains reviews by a renowned group of clinicians and scientists, which consider in great depth the potential involvement of neurogenic inflammation in the pathogenesis of migraine and inhibition of this putative mechanism as a possible m…

  • Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

    Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

    Häftad - 2018 - Engelska - ISBN: 9783319825380

    As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is d…

  • The Hereditary Basis of Rheumatic Diseases

    The Hereditary Basis of Rheumatic Diseases

    Inbunden - 2006 - Engelska - ISBN: 9783764372019

    Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes geneti…

  • Bone Morphogenetic Proteins

    Bone Morphogenetic Proteins

    Häftad - 2012 - Engelska - ISBN: 9783034894463

    From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range…

  • Antimicrobial Peptides and Innate Immunity

    Antimicrobial Peptides and Innate Immunity

    Inbunden - 2013 - Engelska - ISBN: 9783034805407

    Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules…

  • Antimicrobial Peptides and Innate Immunity

    Antimicrobial Peptides and Innate Immunity

    Häftad - 2015 - Engelska - ISBN: 9783034807678

    Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules…

  • The Blood Brain Barrier and Inflammation

    The Blood Brain Barrier and Inflammation

    Häftad - 2018 - Engelska - ISBN: 9783319833088

    This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strict…

  • Mechanisms and Mediators of Neuropathic Pain

    Mechanisms and Mediators of Neuropathic Pain

    Häftad - 2012 - Engelska - ISBN: 9783034894487

    Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury…

  • Novel Inhibitors of Leukotrienes

    Novel Inhibitors of Leukotrienes

    Inbunden - 1999 - Engelska - ISBN: 9783764358846

    Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s. This book covers the steps that have led to the discovery and development of these new drugs and offers detailed des…

  • Occupational Asthma

    Occupational Asthma

    Inbunden - 2010 - Engelska - ISBN: 9783764385552

    Recent developments in occupational asthma research and clinical practice are the focus of this publication. It discusses the contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults, powerful approa…

  • Neuroinflammatory Mechanisms in Alzheimer's Disease

    Neuroinflammatory Mechanisms in Alzheimer's Disease

    Häftad - 2012 - Engelska - ISBN: 9783034895293

    Research into inflammatory mechanisms that may cause damage to the Alzheimer's disease (AD) brain has now been ongoing for nearly two decades. Some two dozen clinical studies have strongly suggested that conventional anti-inflammatory drugs may be u…

  • Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

    Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

    Inbunden - 2017 - Engelska - ISBN: 9783319422510

    As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is d…

  • Cancer and Inflammation

    Cancer and Inflammation

    Häftad - 2012 - Engelska - ISBN: 9783034896009

    How are cancer and inflammation interrelated mechanistically and clinically? Though extensive literature exists on the topic "Cancer and Inflammation", there are relatively few texts that have truly integrated the two in spite of the many common mec…

  • Complement and Kidney Disease

    Complement and Kidney Disease

    Inbunden - 2005 - Engelska - ISBN: 9783764371661

    The understanding how complement relates to glomerular diseaseshas evolved considerably during the last years. Substantialevidence has accumulated that explain how a defective orderegulated complement system results in kidney diseases. Thecombinatio…

  • The Hygiene Hypothesis and Darwinian Medicine

    The Hygiene Hypothesis and Darwinian Medicine

    Inbunden - 2009 - Engelska - ISBN: 9783764389024

    Man has moved rapidly from the hunter-gatherer environment to the living conditions of industrialised countries. The hygiene hypothesis suggests that the resulting reduced exposure to micro-organisms has led to disordered regulation of the immune sy…

  • MIF Family Cytokines in Innate Immunity and Homeostasis

    MIF Family Cytokines in Innate Immunity and Homeostasis

    Häftad - 2018 - Engelska - ISBN: 9783319848822

    The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden co…

  • High Throughput Screening for Novel Anti-Inflammatories

    High Throughput Screening for Novel Anti-Inflammatories

    Häftad - 2012 - Engelska - ISBN: 9783034895781

    Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, comp…

  • Inducible Enzymes in the Inflammatory Response

    Inducible Enzymes in the Inflammatory Response

    Häftad - 2012 - Engelska - ISBN: 9783034897556

    This volume will be of great value to all those researchers in the area of the inflam matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, nam…

  • Inflammation and Stroke

    Inflammation and Stroke

    Häftad - 2012 - Engelska - ISBN: 9783034895088

    Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events…

  • Metalloproteinases as Targets for Anti-Inflammatory Drugs

    Metalloproteinases as Targets for Anti-Inflammatory Drugs

    Häftad - 2012 - Engelska - ISBN: 9783034897242

    This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developm…

  • Vascular Adhesion Molecules and Inflammation

    Vascular Adhesion Molecules and Inflammation

    Häftad - 2012 - Engelska - ISBN: 9783034897532

    The book will provide an overview of the roles of vascular adhesion molecules in health and disease, with chapters on their cell biology, followed by chapters reviewing their importance in specific disease processes. Vascular adhesion molecules are…

  • T Cells in Arthritis

    T Cells in Arthritis

    Inbunden - 1998 - Engelska - ISBN: 9783764358532

    Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempt…

  • Gene Therapy in Inflammatory Diseases

    Gene Therapy in Inflammatory Diseases

    Inbunden - 2000 - Engelska - ISBN: 9783764358556

    Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in thei…

  • Immunology and Drug Therapy of Allergic Skin Diseases

    Immunology and Drug Therapy of Allergic Skin Diseases

    Häftad - 2012 - Engelska - ISBN: 9783034895798

    Allergic skin diseases belong to the most common dermatoses. This book deals with fundamental (in particular immunological aspects) as well as clinical symptoms and therapeutic strategies of the allergic skin diseases. Cells involved in the pathomec…

  • Apoptosis and Inflammation

    Apoptosis and Inflammation

    Inbunden - 1999 - Engelska - ISBN: 9783764357955

    Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. H…

  • NMDA Antagonists as Potential Analgesic Drugs

    NMDA Antagonists as Potential Analgesic Drugs

    Häftad - 2012 - Engelska - ISBN: 9783034894531

    Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, i…

  • Bone Morphogenetic Proteins: Systems Biology Regulators

    Bone Morphogenetic Proteins: Systems Biology Regulators

    Häftad - 2018 - Engelska - ISBN: 9783319837536

    This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and d…

  • Autophagy Networks in Inflammation

    Autophagy Networks in Inflammation

    Häftad - 2018 - Engelska - ISBN: 9783319807195

    Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pa…

  • Cellular Mechanisms in Airways Inflammation

    Cellular Mechanisms in Airways Inflammation

    Häftad - 2012 - Engelska - ISBN: 9783034895835

    Airways inflammation is a complex biological phenomenon resulting from the recruitment and activation of numerous cell types. Airways inflammation contributes to the pathophysiology of airways disease. An understanding of the mechanisms that regulat…

  • Antirheumatic Therapy: Actions and Outcomes

    Antirheumatic Therapy: Actions and Outcomes

    Inbunden - 2004 - Engelska - ISBN: 9783764365950

    Our goal for this book is to examine the contemporary therapy of rheumatoid arthritis (RA) from the increasingly important perspective of impact upon quality of life, costs and long-term health outcomes. For too long the focus has been on short term…

  • MicroRNAs and Other Non-Coding RNAs in Inflammation

    MicroRNAs and Other Non-Coding RNAs in Inflammation

    Inbunden - 2015 - Engelska - ISBN: 9783319136882

    The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohn's disease, diabetes)…

  • Inflammatory and Infectious Basis of Atherosclerosis

    Inflammatory and Infectious Basis of Atherosclerosis

    Häftad - 2012 - Engelska - ISBN: 9783034894876

    In the last ten years, major strides have been made in defining the presence and role of inflammation in atherosclerosis as well as in injury to the tissues that occurs after episodes of ischemia and reperfusion. In sixteen chapters, written by worl…

  • Anti-Inflammatory Drugs in Asthma

    Anti-Inflammatory Drugs in Asthma

    Häftad - 2012 - Engelska - ISBN: 9783034897570

    For some years, international guidelines on the management of asthma have stressed the importance of early intervention with anti-inflammatory drugs to prevent acute asthma exacerbations and to avert chronic inflammatory damage to the airway. Introd…

  • Lipoxygenases in Inflammation

    Lipoxygenases in Inflammation

    Häftad - 2018 - Engelska - ISBN: 9783319802121

    Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase…

  • New Cytokines as Potential Drugs

    New Cytokines as Potential Drugs

    Häftad - 2012 - Engelska - ISBN: 9783034895750

    Over the past ten years, a number of cytokines and growth factors have proven to be as effective therapeutics. While these products have certainly established recombinant biologics as a major pharmaceutical growth sector, the continued interest in t…

  • New Therapeutic Targets in Rheumatoid Arthritis

    New Therapeutic Targets in Rheumatoid Arthritis

    Inbunden - 2009 - Engelska - ISBN: 9783764382377

    This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological ra…